I really can't imagine wanting a dedicated e-reader to replace, say, books. Books are already kind of the perfect medium. But journal articles are another matter; I hate reading them on a computer screen but feel guilty for printing them out (or, rarely, photocopying them). I could really get behind a gadget that simply had JSTOR and Project Muse on it. It could be called "My Precious."
It would need to have Zotero, though.